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4 Challenges for establishing high-fidelity BRAF V600E tumor models 4.1 The challenges of developing models for low-grade gliomas Establishing robust in vitro models that are representative of low-grade CNS tumors, incuding BRAF V600E -mutated CNS tumors is inherently challenging

The patient will be at the heart of everything the NHS does

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Disclosures: Zhiwei Yang: Nothing to Disclose, Nan Liu: Nothing to Disclose, Hongli Zhang: Nothing to Disclose, Ping Chen: Nothing to Disclose, Hui Chen: Nothing to Disclose 2612 THE EFFICACY OF ANTIVIRAL THERAPY FOR HBV-INFECTED CHILDREN: A LARGE-SCALE, MULTICENTER PROSPECTIVE STUDY (SPROUT PROJECT) - AN INTERIM ANALYSIS Hongfei Zhang 1 Qing He 2 Wenxian Ouyang 3 Shuangjie Li 3 Yilan Zeng 4 Jia Shang 5 Fang Wang 2 Lijuan Ouyang 6 Yujing Tang 6 Xiaoguai Liu 7 Pengfei Xu 7 Chuantiao Zhang 8 , 1 Beijing Huatan Integrative Medicine Hospital, Beijing, China, 2 The Third People's Hospital of Shenzhen, Shenzhen, China, 3 Hunan Children's Hospital, Changsha, China, 4 Public Health Clinical Center of Chengdu, Chengdu, China, 5 Henan Provincial People's Hospital, Zhengzhou, China, 6 Xiamen Traditional Chinese Medicine Hospital, Xiamen, China, 7 Xi'an Children's Hospital, Xi'an, China, 8 Shishi General Hospital, Shishi, China Background: Nearly two million children in China are HBsAg-positive but data on antiviral treatment for them are limited

H.-C., Standaert, T., Alptekin, E., Spooner, T., & Paruchuri, V